Inhibition of cardiomyocyte differentiation by cADPR

نویسندگان

  • Wen-Jie Wei
  • Hai-Ying Sun
  • Kai Yiu Ting
  • Li-He Zhang
  • Hon-Cheung Lee
  • Gui-Rong Li
  • Jianbo Yue
چکیده

Background: The role and mechanism of cADPR, an endogenous Ca 2+ mobilizing nucleotide, in cardiomyogenesis remain to be determined. Results: We found that inhibition of the cADPR cascade facilitated cardiomyocyte differentiation of mouse ES cells. Conclusion: The CD38-cADPR-Ca 2+ signaling pathway antagonizes the cardiomyocyte differentiation of mouse ES cells. Significance: Inhibition of cADPR signaling should provide a good approach to enrich functional cardiomyocytes from ES cells.

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تاریخ انتشار 2012